Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
18 results
International journal of radiation oncology, biology, physics, Volume 118, Issue 3, 3 1 2023, Pages 639-649 Predicting Radiation-Induced Lung Injury in Patients With Lung Cancer: Challenges and Opportunities. Kuipers ME, van Doorn-Wink KCJ, Hiemstra PS, Slats AM
Radiation-induced lung injury (RILI) is one of the main dose-limiting toxicities in radiation therapy (RT) for lung cancer. Approximately 10% to 20% of patients show signs of RILI of variable severity. The reason for the wide range of RILI severity and the mechanisms underlying its development are only partially understood. A number of clinical risk factors have been identified that can aid in clinical decision making. Technological advancements in RT and the use of strict organ-at-risk dose con... Abstract
Nature genetics, Volume 55, Issue 10, 1 1 2023, Pages 1778-1779 Author Correction: Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk. Shrine N, Izquierdo AG, Chen J, Packer R, Hall RJ, Guyatt AL, Batini C, Thompson RJ, Pavuluri C, Malik V, Hobbs BD, Moll M, Kim W, Tal-Singer R, Bakke P, Fawcett KA, John C, Coley K, Piga NN, Pozarickij A, Lin K, Millwood IY, Chen Z, Li L, China Kadoorie Biobank Collaborative Group, Wijnant SRA, Lahousse L, Brusselle G, Uitterlinden AG, Manichaikul A, Oelsner EC, Rich SS, Barr RG, Kerr SM, Vitart V, Brown MR, Wielscher M, Imboden M, Jeong A, Bartz TM, Gharib SA, Flexeder C, Karrasch S, Gieger C, Peters A, Stubbe B, Hu X, Ortega VE, Meyers DA, Bleecker ER, Gabriel SB, Gupta N, Smith AV, Luan J, Zhao JH, Hansen AF, Langhammer A, Willer C, Bhatta L, Porteous D, Smith BH, Campbell A, Sofer T, Lee J, Daviglus ML, Yu B, Lim E, Xu H, O'Connor GT, Thareja G, Albagha OME, Qatar Genome Program Research (QGPR) Consortium, Suhre K, Granell R, Faquih TO, Hiemstra PS, Slats AM, Mullin BH, Hui J, James A, Beilby J, Patasova K, Hysi P, Koskela JT, Wyss AB, Jin J, Sikdar S, Lee M, May-Wilson S, Pirastu N, Kentistou KA, Joshi
Cited 18 times since 2023 (15.5 per year) source: EuropePMC
Nature genetics, Volume 55, Issue 3, 13 2 2023, Pages 410-422 Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk. Shrine N, Izquierdo AG, Chen J, Packer R, Hall RJ, Guyatt AL, Batini C, Thompson RJ, Pavuluri C, Malik V, Hobbs BD, Moll M, Kim W, Tal-Singer R, Bakke P, Fawcett KA, John C, Coley K, Piga NN, Pozarickij A, Lin K, Millwood IY, Chen Z, Li L, China Kadoorie Biobank Collaborative Group, Wijnant SRA, Lahousse L, Brusselle G, Uitterlinden AG, Manichaikul A, Oelsner EC, Rich SS, Barr RG, Kerr SM, Vitart V, Brown MR, Wielscher M, Imboden M, Jeong A, Bartz TM, Gharib SA, Flexeder C, Karrasch S, Gieger C, Peters A, Stubbe B, Hu X, Ortega VE, Meyers DA, Bleecker ER, Gabriel SB, Gupta N, Smith AV, Luan J, Zhao JH, Hansen AF, Langhammer A, Willer C, Bhatta L, Porteous D, Smith BH, Campbell A, Sofer T, Lee J, Daviglus ML, Yu B, Lim E, Xu H, O'Connor GT, Thareja G, Albagha OME, Qatar Genome Program Research (QGPR) Consortium, Suhre K, Granell R, Faquih TO, Hiemstra PS, Slats AM, Mullin BH, Hui J, James A, Beilby J, Patasova K, Hysi P, Koskela JT, Wyss AB, Jin J, Sikdar S, Lee M, May-Wilson S, Pirastu N, Kentistou KA, Joshi
Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 580,869 participants, we identified 1,020 independent association signals implicating 559 genes supported by ≥2 criteria from a systematic variant-to-gene mapping framework. These genes were enriched in 29 pathways. Individual variants showed heterogeneity across ancestries, age and smoking... Abstract
Cited 2 times since 2022 (1.1 per year) source: EuropePMC
International journal of cardiology. Heart & vasculature, Volume 42, 19 3 2022, Pages 101086 Dyspnea in patients with atrial fibrillation: Mechanisms, assessment and an interdisciplinary and integrated care approach. van der Velden RMJ, Hermans ANL, Pluymaekers NAHA, Gawalko M, Elliott A, Hendriks JM, Franssen FME, Slats AM, van Empel VPM, Van Gelder IC, Thijssen DHJ, Eijsvogels TMH, Leue C, Crijns HJGM, Linz D, Simons SO
Atrial fibrillation (AF) is the most common sustained heart rhythm disorder and is often associated with symptoms that can significantly impact quality of life and daily functioning. Palpitations are the cardinal symptom of AF and many AF therapies are targeted towards relieving this symptom. However, up to two-third of patients also complain of dyspnea as a predominant self-reported symptom. In clinical practice it is often challenging to ascertain whether dyspnea represents an AF-related sympt... Abstract
Cited 13 times since 2021 (4.7 per year) source: EuropePMC
American journal of physiology. Lung cellular and molecular physiology, Volume 321, Issue 4, 11 2 2021, Pages L775-L786 Disease modeling following organoid-based expansion of airway epithelial cells. Eenjes E, van Riet S, Kroon AA, Slats AM, Khedoe PPSJ, Boerema-de Munck A, Buscop-van Kempen M, Ninaber DK, Reiss IKM, Clevers H, Rottier RJ, Hiemstra PS
Air-liquid interface (ALI) cultures are frequently used in lung research but require substantial cell numbers that cannot readily be obtained from patients. We explored whether organoid expansion [three-dimensional (3D)] can be used to establish ALI cultures from clinical samples with low epithelial cell numbers. Airway epithelial cells were obtained from tracheal aspirates (TA) from preterm newborns and from bronchoalveolar lavage (BAL) or bronchial tissue (BT) from adults. TA and BAL cells wer... Abstract
Cited 3 times since 2020 (0.7 per year) source: EuropePMC
Respiratory research, Volume 21, Issue 1, 12 2 2020, Pages 52 Resistance of the respiratory system measured with forced oscillation technique (FOT) correlates with bronchial thermoplasty response. Goorsenberg AWM, d'Hooghe JNS, Slats AM, van den Aardweg JG, Annema JT, Bonta PI
Background: Bronchial Thermoplasty (BT) is an endoscopic treatment for severe asthma using radiofrequency energy to target airway remodeling including smooth muscle. The correlation of pulmonary function tests and BT response are largely unknown. Forced Oscillation Technique (FOT) is an effort-independent technique to assess respiratory resistance (Rrs) by using pressure oscillations including small airways. Aim: To investigate the effect of BT on pulmonary function, assessed by spirometry, body... Abstract
Cited 1 times since 2019 (0.2 per year) source: EuropePMC
JMIR cardio, Volume 3, Issue 1, 19 3 2019, Pages e9894 Mobile Health for Central Sleep Apnea Screening Among Patients With Stable Heart Failure: Single-Cohort, Open, Prospective Trial. Treskes RW, Maan AC, Verwey HF, Schot R, Beeres SLMA, Tops LF, Tops LF, Van Der Velde ET, Schalij MJ, Slats AM
Background: Polysomnography is the gold standard for detection of central sleep apnea in patients with stable heart failure. However, this procedure is costly, time consuming, and a burden to the patient and therefore unsuitable as a screening method. An electronic health (eHealth) app to measure overnight oximetry may be an acceptable screening alternative, as it can be automatically analyzed and is less burdensome to patients. Objective: This study aimed to assess whether overnight pulse oxime... Abstract
Cited 1 times since 2018 (0.2 per year) source: EuropePMC
International journal of integrated care, Volume 18, Issue 4, 31 5 2019, Pages 15 The Integrated Dyspnea Clinic: An Evaluation of Efficiency. Rietbroek MV, Slats AM, Kiès P, de Grooth GJ, Chavannes NH, Taube C, Bonten TN
Introduction: Dyspnea is a common complaint and in 70 to 90% the origin is pulmonary or cardiovascular. However, referral to the "wrong" specialism could result in diagnostic- and treatment delay. Integrated care by a cardiologist and a pulmonologist could improve this. The aim of the present study was to evaluate whether integrated care for patients with dyspnea is more efficient and effective than regular care. Methods: Consecutive patients (n = 235) seen at our dyspnea clinic after... Abstract
Cited 1 times since 2018 (0.2 per year) source: EuropePMC
International journal of chronic obstructive pulmonary disease, Volume 13, 12 2 2018, Pages 3297-3306 A systematic diagnostic evaluation combined with an internet-based self-management support system for patients with asthma or COPD. van Buul AR, Wildschut TS, Bonten TN, Kasteleyn MJ, Slats AM, Chavannes NH, Taube C
Introduction: An (inter)national systematic approach for patients with asthma COPD referred to secondary care is lacking. Therefore, a novel systematic approach was designed and tested in clinical practice. Methods: This was a retrospective observational study of data from the electronic record system of the Leiden University Medical Center. Asthma and COPD patients were included if they were evaluated with a novel systematic approach or if they had a new record for asthma or COPD and received u... Abstract
Cited 30 times since 2017 (4.3 per year) source: EuropePMC
The European respiratory journal, Volume 49, Issue 5, 1 1 2017, Pages 1602008 Defining asthma-COPD overlap syndrome: a population-based study. Bonten TN, Kasteleyn MJ, de Mutsert R, Hiemstra PS, Rosendaal FR, Chavannes NH, Slats AM, Taube C
Asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) seems an important clinical phenotype, but multiple definitions have been proposed. This study's objectives were to assess the effect of different ACOS definitions on prevalence, patient characteristics and exacerbations.5675 individuals aged 45-65 years, with 846 asthma/COPD patients, were included in the Netherlands Epidemiology of Obesity study between 2008 and 2012, and followed-up for a median of 1.8 years. ACO... Abstract
Cited 15 times since 2013 (1.4 per year) source: EuropePMC
Respiratory medicine, Volume 107, Issue 7, 30 5 2013, Pages 959-966 CD8(+) T cells characterize early smoking-related airway pathology in patients with asthma. Ravensberg AJ, Slats AM, van Wetering S, Janssen K, van Wijngaarden S, de Jeu R, Rabe KF, Sterk PJ, Hiemstra PS
Background: Smoking in asthma occurs frequently and is associated with increased symptom severity, an impaired response to corticosteroids, and accelerated lung function decline. Airway pathology in smoking asthmatics is characterized by neutrophilia and epithelial changes such as goblet cell hyperplasia and increased proliferation. Bronchial CD8(+) T cells are implicated in lung function decline in asthma and COPD. We hypothesized that smoking modifies airway inflammation in asthma by increasin... Abstract
Cited 27 times since 2010 (2 per year) source: EuropePMC
Journal of applied physiology (Bethesda, Md. : 1985), Volume 109, Issue 6, 2 1 2010, Pages 1582-1591 Fluctuations and determinism of respiratory impedance in asthma and chronic obstructive pulmonary disease. Muskulus M, Slats AM, Sterk PJ, Verduyn-Lunel S
Asthma and COPD are chronic respiratory diseases that fluctuate widely with regard to clinical symptoms and airway obstruction, complicating treatment and prediction of exacerbations. Time series of respiratory impedance obtained by the forced oscillation technique are a convenient tool to study the respiratory system with high temporal resolution. In previous studies it was suggested that power-law-like fluctuations exist also in the healthy lung and that respiratory system impedance variabilit... Abstract
Cited 2 times since 2008 (0.1 per year) source: EuropePMC
The European respiratory journal, Volume 32, Issue 5, 1 1 2008, Pages 1135-1137 The secret life of steroids in asthma. Sterk PJ, Yick CY, Slats AM
Cited 8 times since 2008 (0.5 per year) source: EuropePMC
Journal of applied physiology (Bethesda, Md. : 1985), Volume 105, Issue 6, 18 3 2008, Pages 1725-1732 Enhanced airway dilation by positive-pressure inflation of the lungs compared with active deep inspiration in patients with asthma. Slats AM, Janssen K, de Jeu RC, van der Plas DT, Schot R, van den Aardweg JG, Sterk PJ
Deep inspiration temporarily reduces induced airways obstruction in healthy subjects. This bronchodilatory effect of deep inspiration is impaired in asthma. Passive machine-assisted lung inflation may augment bronchodilation compared with an active deep inspiration in patients with asthma by either opening closed airways or by reducing fluid flux across the airway wall during deep inspiration, and thereby increasing the tethering forces on the airway wall. We recruited 24 patients with asthma [1... Abstract
Cited 38 times since 2008 (2.4 per year) source: EuropePMC
The Journal of allergy and clinical immunology, Volume 121, Issue 5, 11 2 2008, Pages 1196-1202 Expression of smooth muscle and extracellular matrix proteins in relation to airway function in asthma. Slats AM, Janssen K, van Schadewijk A, van der Plas DT, Schot R, van den Aardweg JG, de Jongste JC, Hiemstra PS, Mauad T, Rabe KF, Sterk PJ
Background: Smooth muscle content is increased within the airway wall in patients with asthma and is likely to play a role in airway hyperresponsiveness. However, smooth muscle cells express several contractile and structural proteins, and each of these proteins may influence airway function distinctly. Objective: We examined the expression of contractile and structural proteins of smooth muscle cells, as well as extracellular matrix proteins, in bronchial biopsies of patients with asthma, and r... Abstract
Cited 65 times since 2007 (3.8 per year) source: EuropePMC
American journal of respiratory and critical care medicine, Volume 176, Issue 2, 22 4 2007, Pages 121-128 Bronchial inflammation and airway responses to deep inspiration in asthma and chronic obstructive pulmonary disease. Slats AM, Janssen K, van Schadewijk A, van der Plas DT, Schot R, van den Aardweg JG, de Jongste JC, Hiemstra PS, Mauad T, Rabe KF, Sterk PJ
Rationale: Deep inspirations provide physiologic protection against airway narrowing in healthy subjects, which is impaired in asthma and chronic obstructive pulmonary disease (COPD). Airway inflammation has been suggested to alter airway mechanics during deep inspiration. Objectives: We tested the hypothesis that the number of bronchial inflammatory cells is related to deep inspiration-induced bronchodilation in asthma and COPD. Methods: In a cross-sectional study, three modified methacholine c... Abstract
Cited 17 times since 2006 (1 per year) source: EuropePMC
Chest, Volume 130, Issue 1, 1 1 2006, Pages 58-65 Improvement in bronchodilation following deep inspiration after a course of high-dose oral prednisone in asthma. Slats AM, Sont JK, van Klink RH, Bel EH, Sterk PJ
Background: Bronchodilation following deep inspiration is usually impaired in patients with asthma. This might be due to changes in airway mechanics in the presence of inflammation or structural changes within the airways. Although inhaled corticosteroid treatment has been shown to improve airway responses to deep inspiration in patients with asthma, airway inflammation can persist despite inhaled corticosteroid treatment, and thus could still influence the airway mechanics during deep breaths.... Abstract
Cited 83 times since 2005 (4.3 per year) source: EuropePMC
Leukemia, Volume 19, Issue 4, 1 1 2005, Pages 537-544 Causes of death--other than progressive leukemia--in childhood acute lymphoblastic (ALL) and myeloid leukemia (AML): the Dutch Childhood Oncology Group experience. Slats AM, Egeler RM, van der Does-van den Berg A, Korbijn C, Hählen K, Kamps WA, Veerman AJ, Zwaan CM
We analyzed causes of death, other than resistant disease or relapse, in 875 children with acute lymphoblastic leukemia (ALL) and 229 with acute myeloid leukemia (AML), treated on three different Dutch Childhood Oncology Group (DCOG) ALL and three AML protocols. Overall, 23 (2.6%) ALL and 44 (19.2%) AML patients died. Early death (ED, before remission was reached) occurred in nine ALL (1%) and thirty AML (13.1%) patients, including three and ten deaths before treatment was initiated. Chemotherap... Abstract